Controls include limiting the length of time an employee is exposed to hazardous atmospheres.

Infectious agents, the products of infectious agents, or the components of infectious agents presenting a risk of injury or illness.

A ventilated cabinet which serves as a primary containment device for operations involving biohazard materials.

The Class III biosafety cabinet is a totally enclosed, negative pressure, ventilated cabinet of gas-tight construction. Operations within the Class III cabinet are conducted through protective gloves. Supply air is drawn into the cabinet through high-efficiency particulate air filters. Exhaust air is filtered by two high efficiency particulate air filters placed in series or by high efficiency particulate air filtration and incineration, and discharged to the outdoor environment without recirculation.

The Class I biosafety cabinet is an open-fronted negative pressured ventilated cabinet with a minimum inward average face velocity at the work opening of at least 75 feet per minute. The exhaust air from the cabinet is filtered by a HEPA filter and discharged without recirculation.

The Class II biosafety cabinet is an open-fronted, ventilated cabinet. Exhaust air is filtered with a high efficiency particulate air filter (HEPA). This cabinet provides HEPA-filtered downward airflow within the workspace. Class II Cabinets are further classified as type A, type B1, type B2 and type B3. Class II, type A biosafety cabinets may have positive pressure contaminated internal ducts and may exhaust HEPA-filtered air back into the laboratory. Shall provide a minimum inward average face velocity of 75 feet per minute at the work opening. Class II type B1 cabinets have all biologically contaminated internal ducts or plenums under negative pressure or surrounded by negative pressure ducts or plenums, exhaust HEPA filtered air through external ducts to space outside the laboratory, and have HEPA filtered down flow air composed largely of unrecirculated inflow air. Class II type B2 cabinets (also known as "total exhaust" cabinets) have all biologically contaminated internal ducts or plenums under negative pressure or surrounded by negative pressure ducts or plenums, exhaust HEPA filtered air through external ducts to space outside the laboratory, and have HEPA filtered downflow air drawn from the laboratory or outside air. Class II type B3 cabinets (also known as "convertible" cabinets) have all biologically contaminated internal ducts or plenums under negative pressure or surrounded by negative pressure ducts or plenums, exhaust HEPA filtered air through external ducts to space outside the laboratory, and have HEPA filtered downflow air that is a portion of the mixed downflow and inflow air from a common exhaust plenum.

Biosafety levels consist of laboratory practices and techniques, safety equipment, and a laboratory facility appropriate for the operations performed and the hazard posed by the particular biohazard material. The Centers for Disease Control (CDC) and the National Institute of Health (NIH) define the four biosafety levels in the publication, Biosafety in Microbiological and Biomedical Laboratories, 1988 and revisions, and recommend biosafety levels for particular pathogenic microorganisms.

Biosafety in Microbiological and Biomedical Laboratories, Fifth Edition, CDC and National Institutes for Health, 2007, which is hereby, incorporated by reference for the purpose of establishing biosafety requirements in laboratories.

Control measures, such as traffic control, disinfection, and isolation, that are implemented to reduce the risk of transmission of infection into, from, or within an establishment. The purpose of biosecurity measures is to prevent direct or indirect animal-to-animal transmission of zoonotic ATPs, release of pathogens into the environment, and infection of people who may come into contact with animals or areas where animals are housed, or with debris from those areas. The specific biosecurity measures necessary depend on the type of operation conducted by the employer. Typically, no provision for biosecurity other than the use of common sanitation measures is required for incidental removal of animal carcasses or other wastes, unless the activity may result in the introduction of pathogens into areas where animals are kept or housed, or unless the animal is the subject of an applicable alert or disease control order

Human blood, human blood components, and products made from human blood.

Pathogenic microorganisms that are present in human blood and can cause disease in humans. These pathogens include, but are not limited to, hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV).

United States Centers for Disease Control and Prevention

California Department of Public Health and its predecessor the California Department of Health Services

Either of the following: (1) A person who has been diagnosed by a health care provider who is lawfully authorized to diagnose, using clinical judgment or laboratory evidence, to have a particular disease or condition. (2) A person who is considered a case of a disease or condition that satisfies the most recent communicable disease surveillance case definitions established by the CDC and published in the Morbidity and Mortality Weekly Report (MMWR) or its supplements.

A workplace where diagnostic or other screening procedures are performed on blood or other potentially infectious materials.

The combination of personal practices, procedures, safety equipment, laboratory design, and engineering features to minimize the exposure of workers to hazardous or potentially hazardous agents.

The presence or the reasonably anticipated presence of blood or other potentially infectious materials on a surface or in or on an item.

Laundry which has been soiled with blood or other potentially infectious materials or may contain sharps.

Removal or destruction of infectious agents; removal or neutralization of toxic agents.

The removal of hazardous substances from employees and their equipment to the extent necessary to preclude the occurrence of foreseeable adverse health effects.

The use of physical or chemical means to remove, inactivate, or destroy bloodborne pathogens on a surface or item to the point where they are no longer capable of transmitting infectious particles and the surface or item is rendered safe for handling, use, or disposal. Decontamination includes procedures regulated by Health and Safety Code Section 118275.

Infection control procedures as described in Guideline for Isolation Precautions designed to reduce the risk of transmission of infectious agents through contact of the conjunctivae or the mucous membranes of the nose or mouth of a susceptible person with large-particle droplets (larger than 5 mm in size) containing microorganisms generated from a person who has a clinical diseaseor who is a carrier of the microorganism.

A unit that enables a user to have flushing fluid cascading over the entire body.

Any occurrence such as, but not limited to, equipment failure, rupture of containers, or failure of control equipment that may or does result in an uncontrolled significant release of an airborne contaminant.

Exposure to a concentration of an airborne contaminant that would occur if the employee were not using respiratory protection.

(1) A physical attribute built into a needle device used for withdrawing body fluids, accessing a vein or artery, or administering medications or other fluids, which effectively reduces the risk of an exposure incident by a mechanism such as barrier creation, blunting, encapsulation, withdrawal or other effective mechanisms; or (2) A physical attribute built into any other type of needle device, or into a non-needle sharp, which effectively reduces the risk of an exposure incident.

Controls may include working in fume hoods, enclosures, or modify work processes/equipment to decrease the exposure of hazardous atmospheres.

Controls (e.g., sharps disposal containers, needleless systems and sharps with engineered sharps injury protection) that isolate or remove the bloodborne pathogens hazard from the workplace.

A specific eye, mouth, other mucous membrane, non- intact skin, or parenteral contact with blood or other potentially infectious materials that results from the performance of an employee's duties.

Any situation arising from work operation where an employee may ingest, inhale, absorb through the skin or eyes, or otherwise come into contact with a hazardous substance.

A device used to irrigate and flush the eyes.

Locations where hazardous materials and/or equipment are used and/or stored such as shops, kitchens, loading docks, visual/performing art studios, and janitorial storage areas; they are not laboratory areas.

Hepatitis B virus.

Hepatitis C virus

Human immunodeficiency virus.

The HWAR or Hazardous Waste Accumulation Room is located at the back of Building 1. This room is access-controlled and is used to accumulate biohazardous & chemical waste for vendor pickup and disposal. Building 4 also has a Biohazard Cage where biohazardous materials are accumulated for pickup by the vendor as well. Only workers specifically trained in the proper handling of hazardous waste shall have access to these areas. Hazardous Waste Handlers receive initial training and annual retraining.

A facility providing an adequate supply of running potable water, soap and single use towels or hot air drying machines.

The nature of the physical, health or environmental hazard.

A statement assigned to a hazard class and category that describes the nature of the hazards of a hazardous product, including, where appropriate, the degree of hazard.

A material for which there is statistically significant evidence based on at least one study conducted in accordance with established scientific principles that acute or chronic health effects may occur in exposed employees. The term "health hazard" includes materials which are carcinogens, toxic or highly toxic agents, reproductive toxins, irritants, corrosives, sensitizers, hepatoxins, nephrotoxins, neurotoxins, agents that act on the hematopoietic systems, and agents which damage the lungs, skin, eyes, or mucous membranes. The term "physical hazard" includes materials for which there is scientifically valid evidence that it is a combustible liquid, a compressed gas, cryogenic, explosive, flammable, an organic peroxide, an oxidizer, pyrophoric, unstable (reactive), or water-reactive

A Health Threatening or Non-Health Threatening spill, unauthorized, or unexpected release of a hazardous material from primary containment, as defined in any of the referenced laws or regulations.

See HWAR.

Any substance which is a physical hazard or a health hazard or is included in the List of Hazardous Substances prepared by the Director pursuant to Labor Code section 6382.

A physician and surgeon, a veterinarian, a podiatrist, a nurse practitioner, a physician assistant, a registered nurse, a nurse midwife, a school nurse, an infection control practitioner, a medical examiner, a coroner, or a dentist

Substances that produce liver damage (e.g., nitrosamines, carbon tetrachloride).

A filter that is at least 99.97% efficient in removing monodisperse particles of 0.3 micrometers in diameter. The equivalent NIOSH 42 CFR 84 particulate filters are the N100, R100, and P100 filters.

Procedures performed on a person who is a case or suspected case of an aerosol transmissible disease or on a specimen suspected of containing an ATP-L, in which the potential for being exposed to aerosol transmissible pathogens is increased due to the reasonably anticipated generation of aerosolized pathogens. Such procedures include, but are not limited to, sputum induction, bronchoscopy, aerosolized administration of pentamidine or other medications, and pulmonary function testing. High Hazard Procedures also include, but are not limited to, autopsy, clinical, surgical and laboratory procedures that may aerosolize pathogens.

A facility or operation in a facility where the manipulation of specimens or microorganisms is performed for the purpose of diagnosing disease or identifying disease agents, conducting research or experimentation on microorganisms, replicating microorganisms for distribution or related support activities for these processes

Employee and non-employee laboratory personnel who perform laboratory activities whereby they may be exposed to hazardous materials and/or physical hazards potentially encountered in the laboratory area. Employees include faculty and staff and may include research associates, undergraduate and graduate students, post-doctoral researchers, depending on their employment status. Non-employees include visiting scholars and may include research associates, undergraduate and graduate students, post-doctoral researchers, depending on their university affiliation and employment status.

An individual plan prepared by a PI that covers the safety procedures pertinent to activities conducted in his/her laboratory.

The individual in charge of the laboratory. It may be a Principal Investigator (PI), laboratory instructor, or laboratory manager.

Includes both employee and non-employee laboratory personnel who perform research activities, and covers individuals employed in the laboratory workplace who may be exposed to hazardous chemicals in the course of their assignments. Employees include faculty and staff and may include research associates, undergraduate and graduate students, and post-doctoral researchers, depending on their employment status. Non-employees include visiting scholars and may include research associates, undergraduate and graduate students, and postdoctoral researchers, depending on their employment status.

Infection withM. tuberculosisin which bacteria are present in the body, but are inactive. Persons who have LTBI but who do not have TB disease are asymptomatic, do not feel sick and cannot spread TB to other persons. They typically react positively to TB tests

A needle of any type, including, but not limited to, solid and hollow bore needles.

A device that does not utilize needles for: (1) The withdrawal of body fluids after initial venous or arterial access is established; (2) The administration of medication or fluids; and (3) Any other procedure involving the potential for an exposure incident.

Laboratory personnel such as administrative staff, plumbers, and Heating, Ventilation & Air Conditioning (HVAC) technicians entering research laboratories to perform maintenance, administrative, or other non-research laboratory tasks.

Other potentially infectious materials.

Reasonably anticipated skin, eye, mucous membrane, or parenteral contact with blood or other potentially infectious materials that may result from the performance of an employee's duties.

A procedure wherein the needle of a reusable syringe is capped in a sterile manner during use. The technique employed shall require the use of only the hand holding the syringe so that the free hand is not exposed to the uncapped needle.

(1) The following human body fluids: semen, vaginal secretions, cerebrospinal fluid, synovial fluid, pleural fluid, pericardial fluid, peritoneal fluid, amniotic fluid, saliva in dental procedures, any other body fluid that is visibly contaminated with blood such as saliva or vomitus, and all body fluids in situations where it is difficult or impossible to differentiate between body fluids such as emergency response; (2) Any unfixed tissue or organ (other than intact skin) from a human (living or dead); and (3) Any of the following, if known or reasonably likely to contain or be infected with HIV, HBV, or HCV: (A) Cell, tissue, or organ cultures from humans or experimental animals; (B) Blood, organs, or other tissues from experimental animals; or (C) Culture medium or other solutions.

Piercing mucous membranes or the skin barrier through such events as needlesticks, human bites, cuts, and abrasions.

Waste that is any of the following: (1) Liquid or semi-liquid blood or OPIM; (2) Contaminated items that: (A) Contain liquid or semi-liquid blood, or are caked with dried blood or OPIM; and (B) Are capable of releasing these materials when handled or compressed. (3) Contaminated sharps. (4) Pathological and microbiological wastes containing blood or OPIM. (5) Regulated Waste includes "medical waste" regulated by Health and Safety Code Sections 117600 through 118360.

1. LOW RISK: risk level of agents and/or operations having minimal effect on personnel, other animal or plants under ordinary use. This classification is restricted to all etiologic agents designated as Biosafety Level 1 by the CDC. 2. MODERATE RISK: risk level of agents/or operations requiring special conditions for control or containment because of (a) known pathogenicity to personnel, other animals or plants; (b) concentration; or (c) genetic alteration (synergistic effect) with other materials. This classification includes all etiologic agents designated as Class 2 or 3 by the CDC (Biosafety level 2 or 3) and oncogenic viruses specified as moderate risk by the National Cancer Institute (NCI). 3. HIGH RISK: risk level of agents and/or operations requiring additional control measures beyond those for moderate risk. This classification includes all etiologic agents designated Class 4 or 5 by the CDC and oncogenic viruses classified as high risk by the NCI.

Certain toxins of biological origin identified by the United States Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), the United States Department of Agriculture (USDA), and the Animal and Plant Health Inspection Service (APHIS) as posing a potential threat to public health or welfare. Selected biological organisms (bacteria, viruses, fungi) are also regulated as Select Agents.

A mandatory requirement.

A written or electronic record satisfying the requirements of subsection (c)(2).

A recommendation.

A change from negative to positive as indicated by TB test results, based upon current CDC or CDPH guidelines for interpretation of the TB test. Any test, including the tuberculin skin test and blood assays forM. Tuberculosis (BAMT) such as interferon gamma release assays (IGRAs) which: (1) has been approved by the Food and Drug Administration for the purposes of detecting tuberculosis infection, and (2) is recommended by the CDC for testing for TB infection in the environment in which it is used, and (3) is administered, performed, analyzed and evaluated in accordance with those approvals and guidelines. NOTE: Where surveillance for LTBI is required by Title 22, CCR, and the TB test must be approved for this use by the CDPH.

An approach to infection control. According to the concept of Universal Precautions, all human blood and certain human body fluids are treated as if known to be infectious for HIV, HBV, HCV, and other bloodborne pathogens.

Controls that reduce the likelihood of exposure by defining the manner in which a task is performed (e.g., prohibiting recapping of needles by a two-handed technique and use of patient-handling techniques).

A room or defined space in a workplace where hazardous substances are produced or used, and where employees are present.

A disease agent that is transmissible from animals to humans by aerosol, and is capable of causing human disease. Zoonotic ATPs include pathogens that are classified as transmissible either by droplets or by an airborne route.